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Patterns of Spread of Melanoma: Uveal MelanomaUveal melanomas may involve the iris, ciliary body, or, most frequently, the choroids. Localized disease is often treated with local excision, photocoagulation, externalbeam radiotherapy, or enucleation. The uveal tract is poor in lymphatics; therefore metastasis is typically hematogenous in origin. The pattern of spread of uveal melanoma is significantly different from that of cutaneous melanoma. The rates of metastasis to the liver and to the brain differ significantly in patients with skin and uveal melanoma. By far, the liver is the most common site of metastasis for uveal melanoma. Brain Canada Goose Calgary
involvement with metastasis, which occurs in 20 to 40% of patients with metastatic skin melanoma, occurred in less than 3% patients with uveal melanoma. In contrast to patients with cutaneous melanoma, none of the patients with uveal melanoma had tumor spread to the regional lymph nodes. Four percent of patients had metastasis to distant lymph node basins, most Air Max 90 Mens Uk
commonly in the abdomen. The median time from diagnosis of primary uveal melanoma to discovery of metastatic disease was 36 months. The median of survival from date of detection of metastatic disease was 8 months.