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Additionally, the function of receptors in the plasma membrane could be influenced by regulatory phosphorylation and by connection to other proteins that determine the subcellular location of receptors relative to other signaling molecules.One of the most well characterized regulatory pathways for GPCRs is that mediated by the GRK family . After a signaling event, a multistage desensitization process begins with the agonistdependent phosphorylation by a GRK of one or even more serines or threonines located on intracellular domains from the receptor, particularly in the carboxyl terminus and the third intracellular loop (between TM5 and TM6) (Figs.