Pyramidale interneuron EPSCs, but only a modest change in the blockade in s. radiatum interneurons in contrast to Ro25 alone (Figure 1b). Thus, in contrast to pyramidal neurons or pyramidale interneurons, significant functional GluN2B can be found at synapses on s. radiatum interneurons in mature brain slices. These radiatum interneurons exhibited regular firing characteristics in response to injection of depolarizing currents, as opposed to the fast spiking exhibited by the pyramidale interneurons (Supplementary Figure S2), and likely have a distinct role in circuit function.
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