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vitiligo seen with IL2 treatment, the development of autoimmunity appears to be linked to clinical response in patients receiving antiCTLA4. The severity of autoimmune toxicities can range from mild to lifethreatening. Severe diarrhea or hepatitis may require treatment with steroids. Diarrhea not responsive to steroids may require administration of antiTNF agents. Some patients treated with ipilimumab have radiographic evidence of disease progression during treatment before disease stabilizes or regressestherefore, use caution before stopping therapy early.
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